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In a previous study, we observed that health-related quality of life was similar in adult women with Turner syndrome treated with GH in childhood and the general population (11).

We identified several components of the disease or consequences of medical management as factors associated with low health-related quality of life scores: cardiac and otological involvement, induction of puberty after the age of 15 yr, and higher expectations from GH treatment.

In contrast, height or height gain from treatment had no influence (11).

Other aspects of psychosocial functioning, such as self-esteem and social adjustment, have not been systematically evaluated in patients with Turner syndrome (12–15).

Pubertal development must be induced by drug treatment in girls with Turner syndrome presenting primary ovarian failure.

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